Venom peptides and toxins
High Chem offers a line of venom peptides and venom toxins purified from its own venoms or synthesized.
Their purity is high, ranging from 95 to 98%. Their biological activity is well known and described.
They are the fruit of scientific collaborations with various Universities, Scientific Labs and Biological research Centers.
Showing all 6 results
BATRACHOTOXIN from Phyllobates terribilis$200.00 – $1,300.00
Name BATRACHOTOXIN Molecular formula C31H42N2O6 Description The strongest sodium channel activator so far
Alkaloid with a steroid skeleton, an oxazapine ring and a dimethylpyrrole carboxylate moiety , purified from skin extract of the poison dart frog Phyllobates terribilis
Biological activity BTX is the most active alkaloid binding at receptor site-2 on sodium channels. It activates the sodium channel even at very negative membrane potentials and keeps it open permanently by preventing channel inactivation. BTX also changes the selectivity of the channel to Na+ ions and makes it less selective, enabling larger ions to pass through the pore. EC50 (in vitro): 0.1 to 100 nanomolar.
BTX binding induces many allosteric effects on other channel regions, and increases the binding of scorpionalpha-toxins to receptor site-3, of Brevetoxin to receptor site-5, and of pyrethroid insecticides to receptor site-7.
Research tool applicable to the study of the function of sodium channel and the effects of other toxins and of a variety of drugs, including anesthetics, analgesics, antiarrhythmics, anticonvulsants and antidepressants.
Buy NOTEXIN from Notechis scutatus$190.00 – $2,700.00
Name NOTEXIN Molecular formula Np Fraction: C591H878N164O175S16
Ns Fraction: C591H878N166O175S16
Description It is a toxic presynaptic phospholipase A2 (PLA2) with potent myotoxic activity.
– Notexin Np (~60%)
– Notechis Ns (33%), a minor natural variant with K replaced by R in 16
119-amino acid protein with 7 disulfite bonds , from Notechis scutatus snake venom.
Biological activity Notexin exerts both presynaptic (blocks the release of acetylcholine) and myotoxic activities.
ECHICETIN from Echis carinatus sochureki$200.00 – $748.00
Name ECHICETIN Molecular formula A dimer of 256-amino acid: subunit Î± with 133-amino acid and subunit Î² with 123-amino acid Description It binds to platelet glycoprotein Iba and blocks von Willebrand factor (vWF) and Thrombin binding.
Echicetin inhibits aggregation of washed platelets induced by vWF, thrombin or alboaggregin-A. However, when complexed with the pentameric plasma immunoglobulin Mkappa (IgMκ),Echicetinbinds specifically to GPIb and activates platelets
C-type lectin purified from Echis carinatus sochurecki venom
Biological activity Echicetin can be used either to block GPlba functions or, if labelled with 125I or biotin or fluorescein isothiocyanate, to measure GPlba expression levels. In the presence of plasma, Echicetinagglutinates platelets via GPlba and lgM and can be used to assess GPlba expression levels directly, independently of vWF levels or function.
SHORT NEUROTOXIN ALPHA from Naja nigricollis Neurotoxin alpha ; Short Neurotoxin 1$110.00 – $560.00
Name SHORT NEUROTOXIN alpha Molecular formula Description It is an antagonist of the nicotinic acetylcholine receptor at the neuromuscular junction.
61-amino acid peptide with 4 disulfide bridges , from Naja nigricollis snake venom
Biological activity Its binding to acetylcholine receptor in vitro: 95-100 % (KD~ 2-7 10-11 M).
Cross reactivity with:
1) N. nigricollis polyclonal antivenom + + +
2) Monoclonal antibodies to N. nigricollis toxin alpha + + +1m2