Description
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Buy NOTEXIN from Notechis scutatus
Basic phospholipase A2 notexin; Notexine; Notexin Np ; Notexin Ns
Main features :
Notexin is a mixture of 2 119-AA peptides structurally and functionally very similar, extracted from the venom of the Tiger Snake Notechis scutatus: Notexin Np (~60%) and Notexin Ns (33%), a minor natural variant with K replaced by R in 16.
Primary structures: Buy NOTEXIN from Notechis scutatusNp: NLVQFSYLIQ CANHGKRPTR HYMDYGCYCG WGGSGTPVDE LDRCCKIHDD CYSDAEKKGC SPKMSAYDYY CGENGPYCRN IKKKCLRFVC DCDVEAAFCF AKAPYNNANW NIDTKKRCQ
Ns: NLVQFSYLIQ CANHGRRPTR HYMDYGCYCG WGGSGTPVDE LDRCCKIHDD CYSDAEKKGC SPKMSAYDYY CGENGPYCRN IKKKCLRFVC DCDVEAAFCF AKAPYNNANW NIDTKKRCQ
Disulfide bridges for both peptides: 11-71, 27-118, 29-45, 44-99, 51-92, 60-85, 78-90
Molecular weight : 13,574 Da
Buy NOTEXIN from Notechis scutatus Purity: 93%
Biological activity :
Notexin exerts both presynaptic (blocks the release of acetylcholine) and myotoxic activities
Notexin is directly toxic to skeletal muscle (dystrophic effect) upon local application in vivo.
Notexin has also direct nephrotoxicity in experimental mice.
Notexin catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
Buy NOTEXIN from Notechis scutatus
Identification:
| Product name | NOTEXIN | Physical form | |
| CAS No. | 37223-96-4 | Melting point | |
| RTECS | RD3800000 | Solubility | Well in water and saline |
| UNIPROT | P00608;P00609 | Optical Activity | |
| PubChem SID | 134222164 | ||
| PubChem CID | |||
| Purity | > 93 % (HPLC) | ||
| Toxicity(LD50) | IVN-MUS LD50: 25 µg/kg | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable in freeze-dried state. In solution, keep at -20 °C. |
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| Savety Recommendations | For research use only — not intended for food, diagnostic or therapeutic use | ||
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